Angelica root – это.. Что такое angelica root?

Angelica Root Angelica archangelica

angelica root — The root of Angelica archangelica (family Umbelliferae); a tonic and stimulant that may cause nausea; used as a carminative, diuretic, and externally as a counterirritant. * * * angelica root n the dried rhizome and roots of any of several plants …   Medical dictionary

How to Use|remedySide Effects |Plant & Garden|Aromatherapy Oil |Folklore

It is closely related to Dong Quai, one of the most respected female tonics in traditional Chinese medicine. Angelica is a traditional birthing herb used to help bring on a delayed labor and to help expel the placenta following childbirth. Angelica relieves painful and cramping menstruation, (Dysmenorrhea), and brings on delayed menstruation. Angelica is especially good when bloating or cramps are present. (Gladstar, Rosemary)

Angelica has a long history of use in colds , congestion, and fevers. Angelica root is warming and stimulating to the lungs, helping to ease chest congestion (Grieve, Maud)

Documented adverse effects. Emmenagogue effects. Avoid use.

Interactions

Avoid using angelica root concurrently with warfarin.

Adverse Reactions

Furanocoumarins in the plant may cause photodermatitis.

Традиционное использование:В XVI веке дягиль (ангелика) попал из Северной Африки в Европу, преимущественно в теплые районы.Весной в момент первого цветения, которое приходится на 8 мая - день Святого Михаила Архангела, дягиль (ангелика) использовался в магических ритуалах. Растение часто выращивалось в монастырях и называлось "ангельской травой". Масло дягиля входит в состав известных французских ликеров «Шартрез» и «Бенедиктин».Дягиль (ангелика) был популярным садовым растением, пользовался устойчивой репутацией эффективного средства защиты от чумы. В 1665 году, в год великой лондонской чумы, «ангеликовая вода» входила в список королевских рекомендаций, способ ее употребления описывался в специальной брошюре, выпущенной Королевским медицинским колледжем. Известный врачеватель Парацельс высоко ценил дягиль (ангелику), считая его панацеей от всех болезней. Масло дудника (ангелики) часто используется для ароматизации джина и духов, традиционно добавляется в кондитерские изделия.Дягиль (ангелика) с древнейших времен считался лекарственным растением, которое укрепляет сердце, стимулирует кровообращение и положительно действует на иммунную систему. В Европе его использовали для лечения бронхита, простуды, кашля, несварения желудка и стимулирования аппетита.Дягиль (ангелика) обладает свойствами антисептика, поэтому применяется при циститах и ревматических воспалительных процессах.В китайской медицине известно десять сортов дягиля (ангелики), которым приписываются следующие свойства: борьба с бесплодием, укреплением духа, профилактика женских заболеваний. По своим свойствам дягиль уступает только женьшеню.Парфюмеры еще в конце XIX в. обратили внимание на масло корней ангелики из-за экзотического мускусного оттенка его запаха, очень редкого в растительном мире. Такой запах был особенно сильным у порций масла, собираемых в конце отгонки масла с паром.

Метод экстракции:Эфирное масло ангелики из корней получают длительной (до 24 часов) отгонкой с паром из измельченных свежих или сухих корней ангелики двухлетнего возраста. Эфирное масло ангелики из семян получают отгонкой с водяным паром из свежих раздавленных на вальцах семян ангелики.

Выход масла при переработке:Выход эфирного масла из корней составляет 0,1-0,2%, считая на вес свежих корней, и 0,6-1,0% из сухих корней. Французские предприниматели предпочитали вырабатывать масло на предприятиях г. Грасса из привозных сухих корней. В России масло ангелики не производилось и не производится.Выход масла из семян составляет 0,3-1,8%.

Stimulates appetite, carminative, expectorant, diaphoretic, emmenagogue, diuretic


Biochemical Information

Essential oil with phellandrene, angelica acid, coumarin compounds, bitter principle and tannins


The dried root should then be placed in air-tight containers.  The roots should be harvested in the autumn of the first year and thinly sliced longitudinally to hasten the drying process.  Dried leaves because of their aroma are used in the preparation of hops bitters.  The roots, leaves and seeds are for medicinal purposes.  Norwegians make a bread out of the roots.  It has also been a practice in the past in the British Isles to place some fresh angelica in a pot of boiling fish.    It resembles Green Tea.  The flavor is rather bitter and is the color of pale to greenish-grey.  They also have a hot or cold infusion of the dried herb that is drank.  The Finlanders eat the young stems baked in hot ashes.  In Lapland the stalks are regarded as a great delicacy when the leaves are stripped off before flowering and the peel is removed. Icelanders are said to eat both the stem and roots raw, with butter.   The lightly steamed and blanched mid-ribs of the leaf can be used as celery and is quite delicious.  The tender leaflets of the blades of the leaves can be used in place of spinach if the bitter taste does not offend you.  Angelica archangelica is edible when the root is peeled and boiled but most other species are strongly medicinal.

, which is very common to the Pacific coastal area. Angelica hendersoniiOne of the North American angelica species currently being investigated for further medicinal use is

Antiproliferative effect

The tincture from the fruits of Angelica archangelica and the active components were evaluated for an antiproliferative effect, by using the human pancreas cancer cell line, PANC-1, as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC 50 value of 28.6 μg/ml. Strong antiproliferative activity resulted from the two most abundant furanocoumarins in the tincture, imperatorin and xanthotoxin. The contribution of terpenes to this activity was insignificant. Imperatorin and xanthotoxin proved to be highly antiproliferative, with EC 50 values of 2.7 μg/ml and 3.7 μg/ml, equivalent to 10 and 17 μm, respectively. The results indicate that furanocoumarins account for most of the antiproliferative activity of the tincture. [2]

Anti-tumor Activity: The Angelica archangelica leaf extract showed anti-tumor activity. The leaf extract was mildly antiproliferative on the Crl cells with an EC 50 of 87.6 μg/ml. The anti-tumor activity of the extract was expressed in mice by a marked reduction in tumor growth. In the experimental animals, nine out of 11 mice developed none or very small tumors, whereas, the control animals, not receiving the extract, developed significantly larger tumors (P < 0.01), as estimated by the Mann-Whitney U-test. The anti-tumor activity of the leaf extract could not be explained by the antiproliferative activity of furanocoumarins present in the extract.

Conclusion: The results demonstrate the antiproliferative activity in vitro and anti-tumor activity in vivo of a leaf extract from A. archangelica.[31]

Cytotoxic effect

Two chemotypes of essential oils from the fruits of Angelica archangelica L. showed cytotoxic activity. Three samples of essential oils were prepared by steam distillation. Their composition was established with GC / MS. The effects of the oils were examined in PANC-1 human pancreas cancer cells and Crl mouse breast cancer cells in concentrations ranging from 10 - 400 microg/ml, measuring the reduction of the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl) -5- (3-carboxymethoxyphenyl)-2- (4-sulfophenyl) -2H-tetrazolium (MTS) by mitochondrial enzymes. Two types of essential oils were found, differing mainly in the absence or presence of beta-phellandrene. The ED 50 of the oils ranged from 48.6 microg/ml to 108.3 microg/ml for PANC-1 and 48.0 microg/ml to 91.8 microg/ml for Crl cells. It was observed that the cytotoxic activity of the essential oils was independent of the quantity of their main components. [32]

Hepatoprotective effect

The hepatoprotective effect of Angelica archangelica in chronically ethanol-treated mice: A single dose of ethanol (70%, 0.1 ml, p.o.) was used to induce hepatotoxicity in these mice, which resulted in a significant elevation of the activities of serum GOT and GPT. Treatment of mice with AAA (10, 25, and 50 mg/kg p.o.), after two weeks, ameliorated the ethanol-induced hepatotoxicity effects. Hepatotoxicity was evidenced by a significant increase in hepatic lipid peroxidation, which manifested as the presence of malondialdehyde. It was found that AAA inhibited the malondialdehyde formation in mouse liver homogenates both in vitro and in vivo. AAA was a cytoprotective agent effective against chronic ethanol-induced hepatotoxicity, possibly through the inhibition of the production of oxygen free radicals that caused lipid peroxidation, and hence, indirectly protected the liver from oxidative stress. [33]

Anticonvulsant and acute neurotoxic effects

The anticonvulsant and acute adverse effects of imperatorin, osthole, and valproate were determined at 15, 30, 60, and 120 minutes after their systemic (i.p.) administration. The evaluation of the time-course and dose-response relationships for imperatorin, osthole, and valproate in the maximal electroshock seizure test revealed that the compounds produced a clear-cut anti-electroshock action in mice and the experimentally derived ED(50) values for imperatorin ranged between 167 and 290 mg/kg, those for osthole ranged from 253 to 639 mg/kg, whereas, the ED(50) values for valproate ranged from 189 to 255 mg/kg. The evaluation of acute neurotoxic effects in the chimney test revealed that the TD(50) values for imperatorin ranged from 329 to 443 mg/kg, the TD(50) values for osthole ranged from 531 to 648 mg/kg, while the TD(50) values for valproate ranged from 363 to 512 mg/kg. The protective index (as a ratio of TD(50) and ED(50) values) for imperatorin ranged from 1.13 to 2.60, for osthole it ranged from 0.83 to 2.44, and for valproate it ranged from 1.72 to 2.00. In conclusion, both natural coumarin derivatives deserved more attention from a preclinical point of view, as compounds possessing some potentially favorable activities, in terms of suppression of seizures, quite similar to those reported for valproate. [34]

Time-course and dose-response relationships of imperatorin in the mouse maximal electroshock seizure threshold model

Imperatorin (a furanocoumarin isolated from the fruits of Angelica archangelica) showed the anticonvulsant effects in the mouse maximal electroshock seizure threshold model. The threshold for electroconvulsions in mice was determined several times: 15, 30, 60, and 120 minutes after i.p. administration of imperatorin at increasing doses of 10, 20, 30, 40, 50, and 100 mg/ kg. The evaluation of the time-course relationship for imperatorin in the maximal electroshock seizure threshold test revealed that the agent produced its maximum anti-electroshock action 30 minutes after i.p. administration. In this case, imperatorin at doses of 50 and 100 mg/kg significantly raised the threshold for electroconvulsions in mice by 38 and 68% (P < 0.05 and P < 0.001), respectively. The anti-seizure effects produced by imperatorin, 15, 60 and 120 minutes after its systemic (i.p.) administration were less expressed than those observed for imperatorin injected 30 minutes before the maximal electroshock seizure threshold test. Imperatorin produced an anticonvulsant effect in the maximal electroshock seizure threshold test in a dose-dependent manner. [35]

Antifungal and mosquito deterrent activity

Angelica archangelica root oil was evaluated by GC and GC / MS. The main constituents that comprised A. archangelica oil were monoterpene hydrocarbons such as 24.5% alpha-pinene, 13.8% delta-3-carene, 10.1% beta-phellandrene, 8.8% p-cymene, 8.4% limonene, and 6.3% sabinene. Phthalides and monoterpene hydrocarbons were determined to be good systematic markers or chemical fingerprints for A. archangelica root oils. Chemical fingerprinting, by GC / MS, of A. sinensis also confirmed the misidentification of one A. archangelica sample sold in the Chinese market. [36]

While every effort has been taken to ensure that the information contained in these pages is reliable and complete, the notes on hazards, edibility and suchlike included here are recorded information and do not constitute recommendations. No responsibility will be taken for readers’ own actions.

As mentioned earlier, AAO contains more than 60% monoterpenes[11] and monoterpenes have been found to show protective effects against PTZ, picrotoxin-and NMDA-induced convulsions[12,13]. Modulations of glutamatergic and GABAergic transmission are mechanisms indicated for anticonvulsant action of the monoterpenes[13,22,23]. Therefore, it is possible that the antiseizure effect of AAO can be due to the presence of monoterpenes present in AAO and subsequent modulation of glutamatergic and GABAergic transmission.

α-pinene is one of the major constituent of AAO[11]. It is reported that some analogs of pinene prevent the audiogenic seizures in susceptible rats[15] which further strengthens the anti-seizure potential of AAO and it may be related to terpenoids present in the oil. The investigations further revealed that AAO produced motor impairment at antiseizure doses. Some terpenes such as eugenol and anethol have anesthetic, sedative and muscle relaxant effects[24,25]. The terpenes present in the essential oil may be responsible for the observed motor impairment subsequent to CNS depression. Thus, the present investigations conclude that AAO exhibits significant antiseizure activity against chemically and electrically induced seizures in mice and the same can be attributed to terpenes especially monoterpenes present in the Angelica essential oil.

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